组织工程支架的低温沉积制造工艺参数研究*

作者：索海瑞1,岳秀艳1,2,史廷春1,3,姜睿智1,邱建辉1,蔡建辉1，王秋君1，李艳蕾1 日期：2009-04-21/span> 浏览：3100 查看PDF文档

组织工程支架的低温沉积制造工艺参数研究*

索海瑞1,岳秀艳1,2,史廷春1,3,姜睿智1,邱建辉1,蔡建辉1，王秋君1，李艳蕾1
（1.杭州电子科技大学 生物医学工程与仪器研究所，浙江 杭州 310018;2.华北煤炭医学院 成教学院，河北 唐山 063011；
3.河北理工大学 机械工程学院，河北 唐山 063009）

摘要：低温沉积制造是一种新的快速成形技术。为了将这项技术更好地应用于组织工程支架的制造，根据支架孔隙率的要求，按照一定比例将PLGA和珍珠粉混合，配制成浆料，然后利用低温沉积制造工艺制备了网格型的组织工程支架，并得出了适于加工这种材料的一组工艺参数。主要从软件设定、浆料性质、温控调节和速度匹配4个方面入手，研究了在材料配制、分层和成形机制造等一系列工艺过程中参数对成形结果的影响。实验结果表明，制造出的支架结构规则能满足孔隙率的要求。
关键词：快速成形；粘度；温度；喷头速度；低温沉积制造
中图分类号：TH164文献标识码：A文章编号：1001-4551(2009)03-0057-04

Study on low-temperature deposition manufacturing process parameters of tissue engineering scaffold
SUO Hai-rui1, YUE Xiu-yan1,2, SHI Ting-chun1,3, JIANG Rui-zhi1, QIU Jian-hui1,
CAI Jian-hui1, WANG Qiu-jun1, LI Yan-lei1
(1.Institute of Biomedical Engineering and Instrumentation, Hangzhou Dianzi University, Hangzhou 310018, China;
2.Institute of Adult Education, North China Coal Medical Institute, Tangshan 063011, China;
3.College of Mechanical Engineering, Hebei Polytechnic University, Tangshan 063009, Chian)
Abstract: Low-temperature deposition manufacturing(LDM) is a new rapid prototyping technique. To better applying this technique in the tissue engineering scaffold manufacturing, PLGA and pearl powder were mixed in a certain proportion and diluted into slurry according to the requirement of tissue engineering scaffold porosity. Then the slurry was made into a chessboard-form scaffold. A series of parameters were obtained in compounding of the materials, stratifying and manufacturing by the LDM machine. The impact to the modeling results was mainly studied through four aspects: parameters setting in the software, property of the slurry, regulation of the temperature controlling and match of the velocity. The experiment results indicate that the regular-structure scaffold can meet the porosity requirement.
Key words: rapid prototyping; viscosity; temperature; velocity of the nozzle; low-temperature deposition manufacturing(LDM)
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